|
Biographical
Sketch of
Abderrazzak Douhal |
| Abderrazzak Douhal, currently a
Professor of Physical Chemistry at the Universidad de Castilla-La Mancha (Facultad de
Ciencias del Medio Ambiente, Toledo), with a family of two children, Yasmin and Yunas, and
married to Rafaela Fernandez Carretero, was born in Beni Mellal (Morocco). |
| He
received his M.Sc. and Doctor degrees in chemistry from Université Kadi Ayyad (Marrakesh,
Morocco). From 1986 to 1990, he worked at Instituto de Química Física
"Rocasolano" (C.S.I.C., Madrid, Spain). During 1990-1992, he was a fellow of the
Japanese Ministry of Education, Science and Culture and the Japanese Society for the
Promotion of Science (JSPS). He spent two years in a post-doctoral position at the
Institute for Molecular Science (Okazaki, Japan). During 1993, he worked as a research
associate at Laboratoire de Photophysique Moléculaire (Université Paris-Sud/C.N.R.S.,
Orsay, France). From 1994 to 1998, he was an associate Professor of Physical Chemistry at
Universidad de Castilla-La Mancha (Toledo, Spain). In 1995 and 1997, he was a visiting
associate Professor at California Institute of Technology. Since 1999, he has a permanent
postion as a Professor of Physical Chemistry at the same University. Douhal’s
present research is deserved to the study of hydrogen bonding interaction, proton-
and charge-transfer
spectroscopy and real-time dynamics in condensed phase, and in
molecular pockets of chemical and biological systems, and their use in bio- and
nano-technology and environmental science.
Douhal is a member of the American Association for
The Advancement of Science (AAAS), the European Photochemistry Association (EPA) and el
Grupo de Fotoquimica Español (GRUFO). He is a member of the Editorial Board
of Chemical Physics Letters (http://www.elsevier.nl/inca/publications/store/5/0/5/7/0/7/)
and The International Journal of Photo-energy (http://www.photoenergy.org/ijp),
The Intenational Journal of Photoenergy (http://www.photoenergy.org/ijp),
The Chemistry, an Indian Journal and The Physical Chemistry, an Indian
Journal. |
| Thirty Selected Publications of A. Douhal |
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| Femtosecond
Molecular Dynamics of Tautomerization in Model Base Pairs, Nature, 1995. |
Femtochemistry
in Nanocavities: Reactions in Cyclodextrins, J. Phys. Chem. A, 1998. |
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| Femtochemistry
in Nanocavities: Dissociation, Recombination and Vibrational Cooling of Iodine in
Cyclodextrins, Chem. Phys. Lett., 1998. |
Hydrogen
bonding Interactions and Double Proton-Transfer Reactions at Both Gates of Cyclodextrins, Chem.
Phys. Lett., 1998. |
A. Douhal et al. “ Observation of Three Behaviors in Confined Liquid Water
Within a Nanopool Hosting Proton-Transfer Reactions”, J. Phys. Chem. B, 2007,
111, 5487-5493.
FEW SELECTED CONTRIBUTIONS
1. J-L. M. Abboud, A. Douhal, M. J. Arín, M. T. Diez, H.
Homan, G. Guiheneuf "Quantitative Assessment of Solvent-sorting Effects. 1. A
Menschutkin Reaction in Mixed Solvents", J. Phys. Chem. 93, 214 - 220 (1989).
2. R. F. Borkman, A. Douhal, K. Yoshihara, "Picosecond
Fluorescence Decay in Photolysed Lens Protein Alfa-Crystallin", Biochem. 32, Nº 18,
4787 - 4792 (1993).
3. K. Yoshihara, A. Yartsev, Y. Nagasawa, H. Kandori, A.
Douhal, K. Kemnitz, "Femtosecond Intermolecular Electron Transfer Between Dyes and
Electron-donating Solvents", Pure and Appl. Chem. 65, Nº8, 1671 - 1675 (1993).
4. A. Douhal, F. Lahmani, A. Zenhaker-Retien, F.
Amat-Guerri, "Excited-state Intramolecular Proton-transfer In Jet-cooled
2-(2'-Hydroxyphenyl)-5-phenyloxazole", J. Phys. Chem., 98, 12198 - 12205 (1994).
5. A. Douhal, S. K. Kim, A. Zewail, " Femtosecond
Molecular Dynamics of Tautomerization in Model Base Pairs" Nature, 378, 260-263
(1995).
6. A. Douhal, F. Lahmani, A. Zewail, "Proton-Transfer
Reaction Dynamics", Chem. Phys. Special Issue, 207, 477-498 (1996). (Review)
7. A. Douhal, " A Quick Look at Hydrogen Bonds",
Science 276, 221-222 (1997).
8. A. Douhal, F. Amat-Guerri, A. U. Acuña, "Probing
Nanocavities with Proton-transfer Fluorescence", Angew. Chem. Int. Ed. Engl. 36,
Nº13,14, 1514-1516 (1997).
9. M. Chachisvilis, T. Fiebig, A. Douhal, A. H. Zewail,
"Femtosecond Dynamics of a Hydrogen-bonded Model Base Pair in the Condensed Phase:
Double Proton Transfer in 7-Azaindole" J. Phys. Chem. A, 102, 669-673 (1998).
10. A. Douhal, T. Fiebig, M. Chachisvilis, A. H. Zewail,
"Femtochemistry in Nanocavities: Reactions in Cyclodextrins", J. Phys. Chem. A,
102, 1657-1660 (1998).
11. C. R. Mateo, A. Douhal, "A Coupled Proton-transfer
and Twisting-motion Fluorescence Probe for Lipid Bilayers", Proc. Natl. Acad. Sci.
(USA), Vol. 95, 7245-7250 (1998).
12. M. Chachisvilis, I. Garcia-Ochoa, A. Douhal, A. H.
Zewail, "Femtochemistry in Nanocavities: Dissociation, Recombination and Vibrational
Cooling of Iodine in Cyclodextrins", Chem. Phys. Lett. 293, 153-159 (1998).
13. I. García-Ochoa, M. A. Díez López, M. H. Viñas, L.
Santos, E. Martínez Ataz, F. Amat-Guerri, A. Douhal, "Probing Hydrophobic
Nanocavities in Chemical and Biological Systems with a Fluorescent Proton-transfer
Dye", Chemistry, A Eur. J. 5 (3), 897-901 (1999).
14. T. Fiebig, M. Chachisvilis, M. Manger, and A. H. Zewail
, A. Douhal, I. Garcia-Ochoa, and A. de La Hoz Ayuso, "Femtosecond Dynamics of
Double Proton Transfer in a Model DNA Base Pair: 7-Azaindole Dimers in the Condensed
Phase" J. Phys. Chem. A, 103, 7419-7431 (1999).
15. D.P. Zhong, A. Douhal, A.H. Zewail, "Femtosecond
Studies of Protein-Ligand Hydrophobic Binding and Dynamics: Human Serum Albumin",
Proc. Natl. Acad. Sci. (USA) 97, 14052-14055 (2000).
16. A. Douhal, "Femtochemistry in Nanocavities"
en "Femtochemistry" F.C. De Schryver, S. De Feyter, G. Schweitzer (Edits.),
Wiley-VCH, Chapt. 15, 267-279 (2001).
17. A. Douhal, J. Santamaria (Editors),
"Femtochemistry and Femtobiology: Ultrafast Dynamics in Molecular Science",
World Scientific (Singapore), ISBN: 981-02-4866-0, 2002.
18/ J. A. Oraganero, L. Tormo y A. Douhal,
“Caging Ultrafast Proton Transfer and Twisting Motion of
1-Hydroxy-2-acetonaphthone” Chem. Phys. Lett.363 (3-4), 409-414, 2002.
19/ J. A. Organero, A. Douhal, "Confinement
Effects on the Photorelaxation of a Proton Transfer Phototautomer", Chem. Phys.
Lett. 373, 426, 2003.
20/ A. D. Roshal, A. Douhal, “Tuning the
Mechanism of Proton-transfer in a hydroxyflavone Derivative”, Chem. Phys. Lett.
379/1-2, 53-59, 2003.
21/ A. Douhal, A. D. Roshal, J. A. Organero, “
Stepwise Interactions, Sodium Ion Photoejection and Proton-transfer Inhibition
in a Crown-ether and Proton-Transfer Dye”, Chem. Phys. Lett. 381, 519-525, 2003.
22/ A. Douhal, “Ultrafast Guest Dynamics in
Cyclodextrin Nanocavities”, Chem. Rev. 104, 1955-1976,
2004.
23/ A. Douhal, “Breaking, Making, and Twisting of
Chemical Bonds in Gas, Liquids and Nanocavities”, Acc. Chem. Res. 37, 349-355,
2004.
24/ A. Douhal, M. Sanz, M.A. Carranza, J.A.
Organero y L. Santos, “Femtosecond Observation of Intramolecular Charge- and
Proton- Transfer Reactions in a Hydroxyflavone Derivative”, Chem. Phys. Lett.
394, 54-60, 2004.
25/ A. Douhal, M. Sanz, L. Tormo, J.A. Organero,
“Femtochemistry of Inter- and Intramolecular H-bonds Reaction of
3-Hydroxyflavone in H-bond Accepting Solvents”, ChemPhysChem. 6, 410-423,
2005.
26/ L. Tormo, J. A. Organero, A. Douhal, "Effect
of a Nanocavities Confinement on the Relaxation of an Anesthetic Analogous:
Relevance to Encapsulated Drugs Photochemistry", J. Phys. Chem. B, 2005;
109(38); 17848-17854.
27/ A. Douhal, M. Sanz, L. Tormo,”
Femtochemistry of Orange II in Solution and in Chemical and Biological
Nanocavities”,Proc. Natl. Acad. Sci. (USA), 2005, 102(52), 18807-18812.
28/ A. Douhal, “Intra- and Intermolecular Proton
Transfer and Related Processes in Confined Cyclodextrin Nanostructures” en
Volume 1: Physical and Chemical Aspects of Hydrogen Transfer”, J. T. Hynes y
H.-H. Limbach (co-Edits.), “Hydrogen-transfer Reactions”, J.T. Hynes, J.P.,
Klinman, H.-H. Limbach, R. L. Schowen (Eds.), Wiley VCH, ISBN,-13:
978-3-527-30777-7, Oct. 2006.
29/ A. Douhal, Editor,
“Cyclodextrin Materials Photochemistry, Photophysics, and Photobiology”, Vol.
I, 2006, Elsevier, ISBN-13: 978-0-444-52780-6.
30/ A. Douhal, “Fast and Ultrafast Dynamics in
Cyclodextrin Nanostructures”, en “Cyclodextrin Materials Photochemistry,
Photophysics, and Photobiology”, Vol. I, 181-202, 2006, A. Douhal, Edit.,
Elsevier, Amsterdam, ISBN-13: 978-0-444-52780-6.
31/ M. El Kemary, A. Douhal, “Phochemistry and
Photophysics of Cyclodextrin Caged Dugs: Relevance to their Stability and
Efficiency”, en “Cyclodextrin Materials Photochemistry, Photophysics, and
Photobiology”, 79-106, Vol. I, 2006, A. Douhal, Edit., Elsevier, ISBN-13:
978-0-444-52780-6.
32/ M. Gil, J.A. Organero, J. Waluk, A. Douhal,
“Ultrafast Dynamics of Porphycins in Solution”, Chem. Phys. Lett. 2006, 422,
142–146.
33/ M. El-Kemary, J. A. Organero y A. Douhal,
“Fast Relaxation Dynamics of Cardiotonic Milrinone Drug in Water Solutions” J.
Med. Chem. 2006, 49, 3086-3091.
34/ M El-Kemary, J. Organero, L. Santos y A.
Douhal, “Effect of Cyclodextrin Nanocavity Confinement on the Photorelaxation of
Cardiotonic Milrinone Drug”, J. Phys. Chem. B, 2006, 110, 14128-14134.
35/ M. Gil y A. Douhal, “Femtosecond Dynamics of
a Cardiotonic Medicine (Milrinone) in Neutral Water”, Chem. Phys. Lett. 2006,
428 (1-3), 174-177.
36/ G. Angulo, M.A. Carranza y A. Douhal,
“Probing the Behaviour of Confined Water by Proton-Transfer Reactions” Submitted
to J. Phys. Chem. B. 2006, 110, 24231-24237.
37/ M. Gil y A. Douhal, “Femtosecond Dynamics in
Ionic Structures of a Heart Medicine”, Chem. Phys. Lett. 2006, 432 (1-3),
106-109.
38/ A. Douhal, G. Angulo, M. Gil, J.A. Organero, M.
Sanz, L. Tormo, “ Observation of Three Behaviors in Confined Liquid Water Within
a Nanopool Hosting Proton-Transfer Reactions”, J. Phys. Chem. B, 2007, 111,
5487-5493 (con Portada de revista) .
39/ Maged El-Kemary,
Michal Gil y Abderrazzak Douhal, “Relaxation Dynamics of Piroxicam Structures
within Human Serum Albumin Protein”, J Med. Chem. 2007.
Campus Tecnologico de Toledo |
Research Laboratory &
Current Interests |
The four laboratories equipped
with ultrafast (ns to fs regime) laser spectroscopy (emission and transient
absorption techniques + time resolved emission of single molecule) are located in
the building Sabatini (lab. 01) and ICAM at the new "Campus Tecnologico de Toledo" near
the river El Tajo. The laboratory is devoted to different areas of research and
applications of ultrafast lasers to study molecular spectroscopy and dynamics from the
point of view theory and experiment with particular focus on photoinduced proton-
and charge-transfer
reactions and internal rotation in aromatic molecules, including medicines. The current research is centered in
studying and molecular systems for application in nanotechnology,
nanomedicine and environmental science. The
studies of ultrafast dynamics in organised media, and nanostructures constitute the
central theme of the national and international projects being developped in the
four working labs. |
Members and Staffs of the Laboratory |
- Dr. Lucia Santos (currently at the Facultad de Quimicas,
Campus of Ciudad Real).
- Dr. Juan Angel Organero
- Dr. Boyko Koen
- Dr. Michal Gil
Dr. J. F. Sanchez Sanchez
Dr. Abderrazzak Douhal
Departamento de Quimica Fisica
Facultad de Ciencias del Medio Ambiente
Campus Tecnologico de Toledo
Universidad de Castilla-La Mancha
45007, Toledo, Spain.
Phone: + 34-925-265717 (direct) or 34-925-268800, ext: 5409 (office), 5430 (lab.)
Fax: + 34-925-268840.
E-mail:abderrazzak.douhal@uclm.es